A neomycin cassette replaced exons 3, 4 and part of 5, which encodes the amino acids that contribute to the guanine nucleotide binding pocket. Western blot analysis on extracts of brain, spleen and testis tissues did not detect any protein expressed from this allele in homozyogous mice. (J:49140)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count