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Exon 1, which encodes the first 30 amino acids, and part of the first intron were replaced by a lacZ-PGK-neomycin resistance cassette. The lacZ-coding sequence was placed immediately downstream of and in frame with the initiating codon. In addition, a frameshift mutation was introduced into exon 3. Western blot analysis did not detect protein in heads of homozygous mutant E14.5 embryos. Immunohistochemistry did not detect protein in the brachial region of homozygous mutant E11.5 embryos. (J:62985)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
