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Two separate functional peptides, calcitonin and calcitonin gene related peptide-alpha (CGRP-alpha), are derived from this locus by alternative splicing. Calcitonin is encoded by exon 4 and CGRP-alpha by exon 5. Part of exon 5 was replaced with a lacZ gene and neomycin selection gene. Northern blot and RT-PCR analysis on samples derived from spinal root ganglia of homozygous mice demonstrated that no detectable CGRP-alpha transcript was produced from this allele. Western blot analysis on spinal ganglia extracts derived from homozygous mice confirmed that no detectable CGRP-alpha was made. Precursor calcitonin mRNA was detected in the spinal cord. (J:54422)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
