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A loxP site was inserted in intron 1 and a loxP-flanked neomycin-TK cassette was inserted downstream in intron 6. The neomycin-TK cassette was removed by transient transfection with a Cre recombinase expression vector in ES cells prior to the production of chimeric mice and left two loxP sites flanking a region of gene sequence from exon 2 through exon 6. (J:67966)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
