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A CMV-hyTK selection cassette flanked by two loxP sites was inserted approximately 2.6kb upstream of exon 1. A third loxP site was inserted into intron 1. ES cells with this mutation were transiently transfected with a vector driving expression of Cre recombinase. ES cells containing only one loxP site, in which the promoter and exon 1 were deleted, were selected. These cells were injected into blastocyts to generate a the allele designated Vhltm1.1Jae. (J:67505)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
