A neomycin resistance cassette replaced a 3.4 kb fragment of the gene containing the proximal promoter, exons 1, 2, 3, and most of 4. Northern blots of RNA from lungs of homozygous mutant mice showed no detectable transcript for the targeted protein. (J:38867)
Basic Information
Insertion, Intragenic deletion
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count