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The 129P2/OlaHsd strain normally carries the PrP A allotype, with leucine and threonine at residues 108 and 189. In this allele, the sequences encoding these amino acids were altered to instead encode phenylalanine and valine. These changes alter the allotype to one identical to PrP B. (J:29021)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
