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A modified version of exon 4 of the gene was inserted between the last codon and the translational stop site of the gene. This modified version of exon 4 contained a transmembrane anchor. In addition, a neomycin resistance cassette was inserted 150 nucleotides downstream of the polyadenylation signal of the gene. These modifications allowed production of mice that express a membrane-bound form of the protein. (J:53107)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
