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Insertion of an IRES-LacZ sequence followed by a PGK-neomycin resistance cassette into exon 5, which encodes the phosphotyrosine binding (PTB) domain. The authors predict that this insertion would cause the mutant allele to terminate translation within the PTB domain. Western blot analysis and immunoprecipitation studies did not detect wild-type protein in 4 week old homozygous mutant brain. (J:66508)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
