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A neomycin resistance cassette into exon 5 replaced part of the 5' untranslated region of the gene for the gamma2 isoform and the A2 region sequences up to the codon for amino acid 19 (nt 81-342). This disruption is predicted to selectively prevent the synthesis of the gamma2 isoform. RNase protection analysis of E10.5 embryos indicated that the mRNA encoding the gamma2 isoform was mutated in this allele, and that the wild-type transcript for the gamma1 isoform was transcribed. (J:12691)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
