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Mice homozygous for the Numbtm1Ynj allele were mated with transgenic mice which express Cre recombinase under the control of the beta-actin promoter. The presence of Cre resulted in germline deletion of sequences in exons 5 and 6 of the Numb gene that encode the middle portion of the phosphotyrosine binding domain of the protein. C terminus immunoreactivity was not detected in protein extracts from homozygous mutant 10.5 day embryos. (J:62712)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
