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Insertion of a neomycin resistance cassette into exon 8 at the position corresponding to amino acid 75 of the gamma1 isoform disrupted Rarg in the B region common to all isoforms. This disruption is predicted to prevent the synthesis of all RARG isoforms. RNase protection analysis of E13.5 embryos indicated that the mRNAs encoding the both the gamma1 and the gamma2 isoforms were mutated in this allele, and did not detect the wild-type transcript for either isoform. (J:12691)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
