Replacement of two adjacent Pax-binding sites (66 bp) in the regulatory region with a lox-P flanked neomycin cassette. In this derivative of En2tm3Alj, the neomycin cassette was removed via Cre mediated recombination, leaving a loxP site in place of the Pax binding sites. (J:60433)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S6/SvEvTac
Targeted
Insertion, Intragenic deletion
Recessive
1
--
1

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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