Foxn1^nu-StL

This allele comprises a two base pair insertion (GC) in exon 7 causing a frameshift at amino acid 372, adding 134 unique amino acids. The result is a truncated form of the transcription factor protein that retains the DNA binding domain but lacks the activation domain. This mutation is shown to be allelic to Foxn1 by lack of complementation. Uunlike the original nude allele, the protein of this allele is detected in the nucleus. (J:63313)