The insertion of the pGT1.8TM secretory trap vector, containing a beta galactosidase reporter gene, occurred in an intron interrupting the neuropilin-2 coding sequence at cDNA position 2069 nt (amino acid Pro-680). The insertion site is located one-third of the way into the MAM domain of neuropilin-2. This mutation appears to be a loss of function. (J:60158)
Basic Information
Insertion of gene trap vector
Legend:
cx: complex: > 1 genome feature ot: other: hemizygous, indeterminate,... (F): Female
(M): Male
N: normal phenotype
(#): related diseases count