Fancl^gcd

This mutation was identified as a transgene insertion that also deletes approximately 150 kb of genomic sequence at the insertion site. This deletion removes exons 4-14 of Fancl and also removes exons 2-11 of a neighboring gene Vrk2. The transgene contains a fragment of goat DNA. A transgene expressing Vrk2 that was introduced into homozygous mice failed to rescue the phenotype, suggesting that the deletion of Fancl was solely responsible for the phenotype seen in these mice. (J:80424)