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A deletion of the entire transcription unit of the Uncx4.1 gene was generated by introducing a loxP site 2-kb upstream of the transcription start site and a loxP-flanked neomycin cassette 5-kb to the second exon. Following homologous recombination in ES cells, cre recombinase was transiently expressed in order to excise loxP flanked sequences. ES cell lines carrying the deleted allele were used to generate founder mice. (J:62022)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
