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Exon 8 and partial intronic flanking sequence was replaced by a neomycin cassette. RT-PCR analysis demonstrated that transcripts lacking exon 8 were produced from this allele as a result of splicing around the neo gene. However, this mutation event leads to frame shifted sequences downstream from exon 9. No protein product was detected in Western blots of liver extract from homozygous mice. (J:32080)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
