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A neomycin resistance cassette replaced a 687 bp fragment of the gene, which contained the exon encoding MD2. In situ hybridization of parasagittal sections of brains from homozygous mutant mice probed with gene-specific probes showed no detectable mRNA for the targeted gene. Immunoblots of hippocampal membrane extracts from homozygous mutant mice using antibodies against the targeted protein showed no detectable protein. (J:46932)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
