A PGK-neomycin resistance cassette replaced part of exon 1 and all of exons 2 and 3. Northern analysis of poly(A)+ RNA using a probe that corresponds to exon 3 did not detect transcript in homozygous mutant whole E14.5 embryo. In situ RNA hybridization did not detect gene expression in the gut of E14.5 homozygous mutant embryos. (J:29443)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129X1/SvJ
Targeted
Insertion, Intragenic deletion
--
1
--
20

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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