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Genomic sequences encoding the DNA-binding domain in exons 3 and 4 were replaced by a neomycin cassette. RT-PCR analysis on total RNA derived from several tissues of homozygous mice revealed that transcripts corresponding to exon 2 as well as exons 5-9 were present at low levels in homozygous mice. The authors do not rule out the possiblility that some mutant protein could be expressed in homozygotes. (J:30560)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
