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The random insertion of a transgene into the Morc gene also resulted in the deletion of a ~13 kb genomic fragment containing exons 2-4. The transgene contains a tyrosinase gene under the control of a polymerase (RNA) II (DNA directed) polypeptide A (Polr2a) promoter. RT-PCR analysis on RNA derived from testis of homozygous mice confirmed that no wild-type transcript was present; however an aberrant transcript containing transgene sequences fused to exon 5 and downstream sequences was expressed from this allele. (J:56287)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
