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The transgene consisted of 3.5kb of the Hoxa1 regulatory region gene with a lacZ reporter sequence. The transgene inserted into intron 7 and separates exons 7 and 8, which code for the two chondroitin sulfate binding domains. RT-PCR analysis detected truncated mRNA transcripts in homozygous embryos. None of the alternative splice forms of the gene are detected in hearts from homozygous mice. (J:50233)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
