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This allele involved the use of an embryonic stem cell line carrying an ectopic Hoxd11/lacZ transgene located between the resident Hoxd13 and Evx2 genes and flanked at the 3' end by a unique loxP site. A loxPneoloxP cassette was recombined on the same chromosome, downstream of resident Hoxd11. After treatment with Cre recombinase, the resultant deletion removed Hoxd11, Hoxd12, and Hoxd13, but brought the ectopic Hoxd11/lacZ transgene back to the original Hoxd11 locus. Mice homozygous for this deficiency lacked Hoxd11, Hoxd12, and Hoxd13 loci. (J:36443)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Gene Expression
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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References Literature
Title
PMID
Journal
Year
IF
