Gbx2^tm1.1Mrt

A neomycin resistance cassette and one loxP site were inserted into a BamH1 site in an intron; a second loxP site was inserted downstream of the stop codon. To obtain mice in which the floxed region of the gene was deleted, the authors crossed mice heterozygous for this mutation with mice that expressed Cre DNA recombinase in the egg or early embryo under control of promoter elements from the mouse Zp3 gene or human beta-actin gene, respectively. The resulting allele lacks the sequences encoding the homeobox. (J:42110, J:79431)