Two targeting vectors were used to create two targeted mutations, but these were not distinguished in the paper. Vector 582 disrupted the Tal1 gene by replacing the sequences encoding the b-HLH domain with a neomycin gene. Vector 607 disrupted the Tal1 gene by replacing the sequences encoding the b-HLH domain with a hygromycin gene. (J:27458)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S1/Sv-Oca2+ Tyr+ Kitl+
Targeted
Insertion, Intragenic deletion
Recessive
1
1
7

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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