Rbl1^tm1Tyj

A PGK-neomycin cassette replaced sequences in exon 1 and a downstream intron of the Rbl1 gene. The authors predict that the mutant allele will synthesize only the first 22 amino acids of the wild-type protein. RBL1 protein was not detected in embryonic fibroblasts derived from homozygous mutant mice, or in homozygous mutant E18 embryos. Rbl1 transcript was not detected in homozygous mutant E18 embryos. (J:34058)