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The sequences encoding the pre-propeptide region were replaced by a neomycin resistance cassette. RT-PCR analysis demonstrated that the transcript was absent in whole brain RNA derived from homozygous mice. Immunohistochemical analysis demonstrated that the protein was not detectable in sections of the amygdala and cerebral cortex of brains of homozygous mice. (J:17994, J:23082, J:47705)
Basic Information
Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
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| Phenotypes |
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References Literature
Title
PMID
Journal
Year
IF
