A neomycin resistance cassette replaced sequences in exon 2 encoding transmembrane domains 1-7. Northern blot analysis on RNA derived from E12 embryos and from embryonic fibroblasts demonstrated that no detectable transcript was produced from this allele. Furthermore, transcripts from this allele were not detected in various tissues of adult homozygous mice (data not shown). (J:33380)

Basic Information

Allele
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
129S4/SvJae
Targeted
Insertion, Intragenic deletion
--
1
--
72

Phenotypes

Legend:
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes:
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Phenotypes

References Literature

Title
PMID
Journal
Year
IF
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