Gene editing
Cybbtm1Din
Alias:
gp91phox
Cybbtm1
gp91phox-
Nox2-
NOX2-
Nox-2-
PHOX-
X-CGD
Cybbtm1Din
Cybb KO
gp91phox-
gp91-
Basic Information
A neomycin resistance gene was inserted into exon 3. Western blot analysis on extracts of neutrophil-rich peritoneal exudate cells from hemizygous male mice confirmed that no detectable protein was expressed. (J:22868)
Basic Information
MGI ID
Strain of Origin
Allele Type
Mutation
Inheritance
Related Gene
Related Disease
Reference
Phenotypes
Because of their genetic and physiological similarities with humans, mouse models are essential for understanding human illnesses. Advances in molecular biology and gene editing improve disease replication in mice, allowing researchers to get a better understanding of disease causes, identify biomarkers, and create treatments.
Legend：
hm: homozygous
ht: heterozygous
cn: conditional genotype
cx: complex: > 1 genome feature
tg: involves transgenes
ot: other: hemizygous, indeterminate,...
(F): Female
(M): Male
phenotype observed
N: normal phenotype
(#): related diseases count
Phenotypes：
Show/Hide columns
| Phenotypes |
|---|
References
Disease models are key instruments in biomedical research, and their literature reports are critical to the advancement of research. These publications provide researchers with a comprehensive theoretical foundation by detailing the design procedures, application regions, and outcomes analysis of disease models.
Title
PMID
Journal
Year
IF
