Cacna1a^tg-la

This mutant allele comprises a G-to-A nucleotide substitution, changing the splice donor consensus sequence at the 5' end of intron 42 from G-gt to G-at. This abolishes or greatly reduces the efficiency of the splice site and results in aberrant transcripts that skip exon 42 or retain intron 42, both of wich are out-of-frame alterations. (J:36596)