Hmgb2 - high mobility group box 2

Enables cis-regulatory region sequence-specific DNA binding activity and protein domain specific binding activity. Involved in several processes, including regulation of gene expression; regulation of stem cell proliferation; and response to lipopolysaccharide. Acts upstream of or within several processes, including male gonad development; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and spermatid nucleus differentiation. Located in several cellular components, including chromatin; extracellular space; and nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; retina; and urinary system. Orthologous to human HMGB2 (high mobility group box 2). [provided by Alliance of Genome Resources, Apr 2022]