Human
CD86 - CD86 Molecule
Alias:
B70
B7-2
B7.2
LAB72
CD28LG2
Basic Information
Sequence Homology
Related Diseases and Mutations
Transcripts & Proteins
Gene Expression
Interactions
Related Mouse Models
Related Drugs
References Literature
This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]
Basic Information
NCBI
Transcripts
Exons
Length
MW (kDa)
Mutations
Related Diseases
Related Mouse Models
Reference
5
7
65775 bp
37.68
16
--
4
15
CD86 Genetics information (+)
GRCh38
Chr 3: 122055362 - 122121136
Adjacent gene of CD86:6
Sequence Homology
Gene Length
Human
Chr 3
65775 bp
Mouse
Chr 16
97122 bp
Rat
Chr 11
58624 bp
Exon Count
Human
NM_175862.5
7
Mouse
NM_019388.3
7
Rat
NM_020081.2
7
Transcript Length
Human
NM_175862.5
2720 bp
Mouse
NM_019388.3
2539 bp
Rat
NM_020081.2
1608 bp
homology
Sequence Alignment
Human
NM_175862.5
100%
Mouse
NM_019388.3
65.5%
Rat
NM_020081.2
61.2%
Protein Length
Human
NP_787058.5
329 aa
Mouse
NP_062261.3
309 aa
Rat
NP_064466.1
313 aa
Protein homology
Sequence Alignment
Human
NP_787058.5
100%
Mouse
NP_062261.3
47.7%
Rat
NP_064466.1
46.0%
Related Diseases and Mutations
#
Disease
Anatomical Category
Score
Mutations
No data available
Transcripts & Proteins
There are 5 transcripts and 5 protein isoforms for CD86 gene.
Table View
Tile View
#
Transcript
Length(nt)
Exon Count
CDS(bp)
Protein
Length(aa)
1
2720
7
990
NP_787058.5
329
2
2840
7
972
NP_008820.4
323
3
2696
6
828
NP_795711.2
275
4
2670
6
744
NP_001193854.2
247
5
2384
6
654
NP_001193853.2
217
* This data comes from NCBI.
Gene Expression
Tissue-specific RNA expression
Organ
Abundance
Alphabetical
Nervous system
Endocrine & Immune system
Respiratory & Circulatory system
Digestive system
Urinary & Reproductive system
Other systems
Cell-specific RNA expression
Organ
Abundance
Alphabetical
Brain
Endothelial
Eye
Female reproductive system
Gastrointestinal tract
Kidney & Urinary bladder
Liver & Gallbladder
Lung
Lymphoid
Male reproductive system
Mesenchymal
Myeloid
Proximal digestive tract
Skin
Interactions
There is currently no available transcript or protein sequence found to be associated with the gene.
Related Mouse Models
Type
Name
MGI
Strain of Origin
Publications
No data available
Related Drugs
Name
CAS Number
Status
Phase
Link
Abatacept
332348-12-6
Approved
Phase 4
Belatacept
706808-37-9
Approved
Phase 3
Dexamethasone
50-02-2
Approved
Phase 2
Antithymocyte immunoglobulin (rabbit)
308067-60-9
Approved
Not
Bryostatin 1
83314-01-6
Investigational
Not
Indomethacin
53-86-1
Approved
Not
Pamidronic acid
40391-99-9
Approved
Not
Roxithromycin
80214-83-1
Approved
Not
Terfenadine
50679-08-8
Approved
Not
9 Results, 10 per Page
1
References Literature
Title
PMID
Journal
Year
IF
No Data Found!
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Mutation Direct
Sequence
Comparison
Al agent
Sources
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