Madd - MAP-kinase activating death domain

Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of growth hormone secretion and negative regulation of pancreatic amylase secretion. Located in cytosol; nucleus; and synaptic vesicle. Is active in synapse. Biomarker of transient cerebral ischemia. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Apr 2022]