Vangl2 - VANGL planar cell polarity 2

Involved in axon guidance; cell migration involved in kidney development; and morphogenesis of an epithelium. Acts upstream of or within several processes, including animal organ development; morphogenesis of an epithelium; and regulation of signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral plasma membrane; and stress fiber. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neural ectoderm; and sensory organ. Used to study neural tube defect. Human ortholog(s) of this gene implicated in neural tube defect. Orthologous to human VANGL2 (VANGL planar cell polarity protein 2). [provided by Alliance of Genome Resources, Apr 2022]