Gpnmb - glycoprotein (transmembrane) nmb

Enables heparin binding activity and integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and positive regulation of protein phosphorylation. Acts upstream of or within cell adhesion. Located in cytoplasmic vesicle. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; eye; heart ventricle; and mesenchyme derived from neural crest. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary localized cutaneous amyloidosis 3. Orthologous to human GPNMB (glycoprotein nmb). [provided by Alliance of Genome Resources, Apr 2022]