Ptch1 - patched 1

Predicted to enable several functions, including cholesterol binding activity; cyclin binding activity; and signaling receptor binding activity. Involved in several processes, including commissural neuron axon guidance; gland development; and response to estradiol. Located in growth cone; nucleus; and postsynaptic density. Human ortholog(s) of this gene implicated in basal cell carcinoma; holoprosencephaly; holoprosencephaly 7; and nevoid basal cell carcinoma syndrome. Orthologous to human PTCH1 (patched 1). [provided by Alliance of Genome Resources, Apr 2022]