Trpc6 - transient receptor potential cation channel, subfamily C, member 6

Enables several functions, including ATPase binding activity; clathrin binding activity; and cytoskeletal protein binding activity. Involved in several processes, including cellular response to hydrogen peroxide; generation of neurons; and positive regulation of peptidyl-threonine phosphorylation. Located in plasma membrane. Used to study focal segmental glomerulosclerosis; kidney disease; and transient cerebral ischemia. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]