Enables double-stranded DNA binding activity; protein domain specific binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleolus. Part of protein-containing complex. Human ortholog(s) of this gene implicated in West Nile fever. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Apr 2022]