Tek - TEK receptor tyrosine kinase

Enables growth factor binding activity. Involved in several processes, including endochondral ossification; response to cAMP; and response to estrogen. Predicted to be located in several cellular components, including basolateral plasma membrane; centriolar satellite; and microvillus. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Predicted to colocalize with actin filament and stress fiber. Biomarker of several diseases, including acute kidney tubular necrosis; brain ischemia; gastric ulcer; goiter; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]