Enpp1 - ectonucleotide pyrophosphatase/phosphodiesterase 1

Enables phosphodiesterase I activity. Involved in several processes, including brain development; cellular response to cAMP; and cellular response to mechanical stimulus. Located in several cellular components, including dendrite; neuronal cell body; and synapse. Biomarker of aortic valve disease 1. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). [provided by Alliance of Genome Resources, Apr 2022]