Twist1 - twist family bHLH transcription factor 1

Predicted to enable several functions, including E-box binding activity; bHLH transcription factor binding activity; and protein homodimerization activity. Involved in several processes, including odontogenesis; positive regulation of epithelial cell proliferation; and roof of mouth development. Located in nucleus. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in Saethre-Chotzen syndrome; Sweeney-Cox syndrome; acrocephalosyndactylia; and craniosynostosis. Orthologous to human TWIST1 (twist family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]