Ciita - class II, major histocompatibility complex, transactivator

Predicted to enable DNA-binding transcription factor binding activity; protein C-terminus binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to electrical stimulus; cellular response to exogenous dsRNA; and regulation of macromolecule biosynthetic process. Located in cell surface. Used to study periapical periodontitis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator). [provided by Alliance of Genome Resources, Apr 2022]