Enables endopeptidase activity and enzyme binding activity. Involved in proteolysis involved in cellular protein catabolic process. Located in extracellular space; intracellular membrane-bounded organelle; and plasma membrane. Human ortholog(s) of this gene implicated in COVID-19; conjunctivitis; myocardial infarction; plasminogen deficiency type I; and thrombophilia. Orthologous to several human genes including PLG (plasminogen). [provided by Alliance of Genome Resources, Apr 2022]