Xrcc1 - X-ray repair cross complementing 1

Predicted to enable enzyme binding activity and oxidized DNA binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including base-excision repair; response to hypoxia; and response to xenobiotic stimulus. Located in nucleus. Used to study in situ carcinoma. Biomarker of asphyxia neonatorum; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 26; carcinoma (multiple); hematologic cancer (multiple); hepatitis A; and reproductive organ cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1). [provided by Alliance of Genome Resources, Apr 2022]