Hcn1 - hyperpolarization-activated cyclic nucleotide-gated potassium channel 1

Enables identical protein binding activity; phosphatidylinositol phosphate binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to interferon-beta; maternal behavior; and response to L-glutamate. Located in several cellular components, including basolateral plasma membrane; dendrite; and neuronal cell body. Used to study anxiety disorder and mood disorder. Biomarker of complex cortical dysplasia with other brain malformations; epilepsy (multiple); and meningitis. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 24 and generalized epilepsy with febrile seizures plus 10. Orthologous to human HCN1 (hyperpolarization activated cyclic nucleotide gated potassium channel 1). [provided by Alliance of Genome Resources, Apr 2022]