Dnmt1 - DNA methyltransferase 1

Enables several functions, including DNA (cytosine-5-)-methyltransferase activity; estrogen receptor binding activity; and histone deacetylase binding activity. Involved in several processes, including DNA metabolic process; cellular response to growth factor stimulus; and nervous system development. Located in cytoplasm; neuronal cell body; and nucleus. Part of protein-containing complex. Used to study choline deficiency disease and lung carcinoma. Biomarker of choline deficiency disease; congenital heart disease; congestive heart failure; liver disease (multiple); and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Graves' disease; autosomal dominant cerebellar ataxia, deafness and narcolepsy; hereditary sensory neuropathy; hereditary sensory neuropathy type 1E; and lung non-small cell carcinoma. Orthologous to human DNMT1 (DNA methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]