Cacng2 - calcium voltage-gated channel auxiliary subunit gamma 2

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including eye blink reflex; positive regulation of AMPA receptor activity; and positive regulation of protein localization to basolateral plasma membrane. Located in several cellular components, including cell surface; cerebellar mossy fiber; and postsynaptic density membrane. Part of AMPA glutamate receptor complex. Biomarker of childhood absence epilepsy. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 10. Orthologous to human CACNG2 (calcium voltage-gated channel auxiliary subunit gamma 2). [provided by Alliance of Genome Resources, Apr 2022]