Usp8 - ubiquitin specific peptidase 8

Enables thiol-dependent deubiquitinase. Involved in endosome organization and protein deubiquitination. Acts upstream of or within Ras protein signal transduction. Located in acrosomal membrane; cytosol; and midbody. Is extrinsic component of endosome membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in ACTH-secreting pituitary adenoma. Orthologous to human USP8 (ubiquitin specific peptidase 8). [provided by Alliance of Genome Resources, Apr 2022]