Gsk3b - glycogen synthase kinase 3 beta

Enables several functions, including ATP binding activity; protein kinase activity; and signaling receptor binding activity. Involved in several processes, including regulation of neuron projection development; regulation of synapse organization; and response to peptide. Located in several cellular components, including dendritic spine; membrane raft; and microtubule. Part of beta-catenin destruction complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Used to study several diseases, including middle cerebral artery infarction; myocardial infarction; neurodegenerative disease (multiple); sciatic neuropathy; and vascular dementia. Biomarker of several diseases, including artery disease (multiple); diabetic encephalopathy; mental depression; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]